Grant-funded Project Nr. 253/2001/B-CH/PřF
Final Report

Project title:Polarographic and voltammetric determination of genotoxic and ecotoxic nitro and azo compounds
Research leader:Doc. RNDr. Jiří Barek, CSc.
Co-researcher: Mgr. Alexandr Muck; Mgr. Veronika Quaiserová; RNDr. Michal Dřevínek; MSc. Shanmugan Kumaran; Mgr. Karolina Pecková; Mgr. Jan Fischer; Mgr. Radek Štěpán; Jana Kolářová; Mgr. Karel Čížek
Period of project:2001-2003
Overall grant:240 000 CZK

Project Results

Polarographic and voltammetric determination of trace amounts of several genotoxic or ecotoxic azo or nitro compounds was developed, namely of nitro derivatives of biphenyl, pyrene, and naphthalene (see Barek J., Zima J., Pecková K., Quaiserová V.: Electrochemical Determination of Biologically Active Organic Compounds. Zborník prispevkov - 53.zjazd chemických spoločností, Banská Bystrica 2001, p..9), of nitro and azo compounds using silver solid amalgam electrodes (see Barek J., Mejstřík V., Zima J.: Are Mercury Electrodes Realy Obsolete Sensors? Book of Abstracts - „US-CZ Workshop on Electrochemical Sensors Prague 2001“ (ISBN 80-86238-15-6), Czech Chemical Society, Prague 2003, p.4), of 1,5-dinitronaphthalene (see Kumaran Shanmugam, Barek J., Zima J.: Polarographic and Voltammetric Determination of 1,5-Dinitronaphthalene. Moderní elektrochemické metody XXII (ISBN 80-86238-22-9), p. 58. Česká společnost chemická, Praha 2002), of 2-aminofluorene and  2,7-diaminofluorene at carbon paste electrode (see Armalis S., Novikova N., Kubiliene E., Zima J., Barek J.: Voltammetric Determination of 2-Aminofluorene and 2,7-Diaminofluorene using Carbon Paste Electrode. Anal. Lett. 35, 1551 (2002)), of polycyclic aromatic amines using cyclodextrin modified carbon paste electrode (see Ferancová A., Korgová E., Labuda J., Zima J., Barek J.: Cyclodextrin modified Carbon Paste Electrodes as Sensors for the Determination of Carcinogenic Polycyclic Aromatic Amines. Electroanalysis 14,1 (2002)), of carcinogenic nitrobiphenyls (see Štěpán R., Barek J., Mejstřík V., Zima J.: Voltammetric Determination of Carcinogenic Nitrobiphenyls at a Hanging Mercury Drop Electrode. Sensors 3,   43 (2003)}, of 1,3-dinitronaphthalene (see Kumaran Shanmugam, Barek J., Zima J.: Polarographic and Voltammetric Determination of 1,3-Dinitronaphthalene. Sborník Moderní elektrochemické metody XIII (ISBN 80-86238-29-6), str.24. Česká společnost chemická, Praha 2003)), of selected cytostatics using silver solid amalgam electrode (see Barek J., Fischer J., Konečná B., Kratzer J., Hrušková M., Navrátil T., Novotný L., Yosypchuk B., Zima J.: Voltammetric Determination of Cytostatics Using Silver Solid Amalgam Electrode. Sborník Moderní elektrochemické metody XIII (ISBN 80-86238-29-6), str. 16. Česká společnost chemická, Praha 2003) and of N,N-dimethyl-4-amino-2’-carboxyazobenzene using the same electrode (see  Barek J., Dodova E., Navrátil T., Yosypchuk B., Novotný L., Zima J.: Voltammetric Determination of N,N-Dimethyl-4-amino-2’-carboxyazobenzene at Silver Solid Amalgam Electrode. Electroanalysis 2003, 15, 1778). Two reviews were published summarizing the achieved results (see Barek J., Zima J.: Eighty Years of Polarography - History and Future. Electroanalysis 15, 467 (2003) and Barek J.: Modern Electroanalytical Methods in Environmental Analysis. Annals West.Univ. Timisoara, Ser.Chim. 11, 177 (2002).